Which Weight-Loss Drug Is Better: Wegovy or Zepbound?
With more people taking the weight-loss drugs Wegovy and Zepbound, one question inevitably arises: which one is more effective?
In a press release, Lilly announced that in its latest trial comparing its medication, Zepbound, to Wegovy, made by Novo Nordisk, people randomly assigned to receive Zepbound lost about 20% of their body weight after about 18 months, while those taking Wegovy lost nearly 14% of their body weight.
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Wegovy (semaglutide) and Zepbound (tirzepatide) both target a group of hormones that the body makes called incretins. Wegovy works on the GLP-1 hormone, which suppresses appetite and signals the pancreas to produce insulin to break down sugars in food. Zepbound works on both GLP-1 and GIP, another hormone that stimulates insulin production. Separate studies conducted by the respective manufacturers have showed that Zepbound, with its dual-acting effect, was linked to more weight loss than Wegovy, but until now, no studies have compa..