The Health Risks and Benefits of Weight-Loss Drugs
The newest weight-loss drugs, Wegovy and Zepbound, are incredibly popular. But doctors are still learning about all of the ways they affect the body—both helpful and harmful—beyond reducing weight.
In report published in Nature Medicine, Dr. Ziyad Al-Aly, assistant professor of medicine at Washington University School of Medicine in St. Louis, and his colleagues performed a comprehensive analysis on the health outcomes associated with the drugs known as GLP-1 receptor agonists. These medications began as diabetes treatments to lower blood glucose levels and have now been approved to help people without diabetes lose weight.
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But because they have been used for longer as diabetes treatments, Al-Aly’s team studied the health records of more than two million people with diabetes in the Veterans Affairs database, some of whom were taking the GLP-1 medications and some who took other diabetes treatments. They tracked health outcomes over about four years ..